2018 Robert Hooke Lecture
Luminescent Dots for Multiplexing Cytometry and Super-Resolution Imaging
University of Technology Sydney, Australia
Distinguished Professor Dayong Jin is a former ISAC Scholar (awarded in 2007). He directs the Australian Research Council IDEAL Research Hub and Institute for Biomedical Materials & Devices (IBMD), at the University of Technology Sydney. His research has been in the physical, engineering and interdisciplinary sciences. He is a technology developer with expertise covering optics, luminescent materials, sensing, automation devices, microscopy imaging, and analytical chemistry to enable rapid detection of cells and molecules and engineering of sensors and photonics devices. Prof Jin is the winner of the Australian Museum Eureka Prize for Interdisciplinary Scientific Research in 2015, the Australian Academy of Science John Booker Medalist in 2017, and the Prime Minister’s Malcolm McIntosh Prize for Physical Scientist of the Year 2017.
Advances in super-resolution fluorescence imaging have enabled revolutionary new insight in the spatial and temporal behavior of the cell. These developments have resulted in a need for the development of robust probes to facilitate long-term tracking of single molecules and real-time super-resolution imaging of sub-cellular structures. In his lecture, Professor Jin will first showcase several new nanotechnology approaches to super-resolution imaging by leveraging optical-switching properties of new classes of luminescent nanoparticles, unlocking new modes of super-resolution microscopy with much higher photon yields than are currently available. He will then summarize his recent achievements by engineering time-resolved photonics devices and reagents to find cells earlier, quicker and with better resolution.
These include the discovery of the Super Dots for single molecule detection and point-of-care diagnostics (Nature Nanotechnology 2013), demonstration of a time-domain multiplexing technology for high throughput biotechnology discoveries (Nature Photonics; Nature Communication 2014), creation of the large library of contrast agents for multi-functional bio-imaging and nanomedicine (Nature Communications 2016), invention of a low-power high contrast super resolution microscopy by achieving the highest optical resolution of 1/36 of the excitation wavelength (Nature 2017), and the new development of a microscopy technique, aimed at improving the resolution and sensitivity of nanoscale imaging, enabling the human eye to track a single molecule and inspect its behaviour inside a living cell (Light: Science & Applications 2018).